Team
Principal Consultants
Meade Medaugh, P.E.Founding Member || Principal Consultant, Processes
Meade Medaugh, P.E., is the Founder and Process Lead at Dynamic Engineering Solutions, bringing 15 years of dedicated experience in the biopharmaceutical industry. As a leader in bioprocess innovation, Meade holds degrees in both biochemistry and chemical engineering and specializes in bioprocess design, scale-up, and manufacturing.
He has successfully supported over 25 products from pre-clinical optimization to post-commercial launch. This extensive experience inspired him to found DES with a vision to bring crucial knowledge and efficiency to the commercialization of desperately needed therapies.
Prior to founding DES, Meade held several leadership positions in both startups and late-stage commercial companies across all biologics modalities. He is driven by a scientific rigor to produce safe, high-quality drug products that enable wider patient access by lowering manufacturing costs—the core principle upon which DES was founded.
Isaac G. JeganathanFounding Member || Principal Consultant, Supply Chain & Procurement
Isaac brings more than 25 years of experience in bio-pharmaceutical manufacturing, holding leadership roles with industry giants Pfizer, GSK and Moderna. Isaac has extensive experience building high-performing teams, transforming operations, negotiating contracts and implementing ERP systems worldwide.
Isaac has successfully launched multiple billion dollar blockbuster drugs, flawlessly executed over 30 technology transfers of globally commercialized products, and generated billions of dollars of bottom-line savings by implementing network optimization strategies.
Isaac received his MBA from Fordham University and a B.S. in Chemical Engineering from Columbia University.
Jeannine LarrieuxPrincipal Consultant
Jeannine Larrieux is a pharmaceutical consultant with over 30 years of experience specializing in Quality, Compliance, and Analytical CMC for Small Molecules, Biologics (ADCs, mAbs, Biosimilars), and advanced Gene Therapies (CAR-T, AAV, LVV).
She has led QC and Analytical strategy, regulatory submissions (IND, CTA, BLA, NDA), and technical transfers across clinical and commercial phases. Her expertise includes developing and executing remediation plans in response to FDA 483s, building robust quality systems, and implementing stability and raw material programs that drive regulatory confidence.
Jeannine is known for her integrity, scientific rigor, and commitment to patient safety, helping organizations uphold compliance while accelerating innovation.
Today, Jeannine works with biopharma organizations to strengthen compliance frameworks, ensure data integrity, and support analytical lifecycle management under global regulations. She is RAPS-certified in pharmaceuticals, biologics, and medical devices.
Senior Consultants
Matthew Pontrelli, M.S. Senior Consultant, Process Development & CMC
Matthew brings over a decade of specialized expertise in PD and CMC, with deep technical knowledge spanning early-stage innovation through late-stage commercialization of biologics products. His approach integrates Quality by Design principles with advanced statistical methods, leveraging Design of Experiments (DOE) and multivariate analysis to develop robust, commercially viable processes. Matthew has extensive experience in late-stage process characterization, including scale-down model qualification, parameter classification, and in-process attribute limit determination, with direct support of PPQ readiness activities and validation protocol development.
His technical leadership encompasses both upstream and downstream unit operations, with particular depth in chromatography, tangential flow filtration, and viral clearance validation. A skilled technical writer, Matthew has authored comprehensive process descriptions, regulatory documentation, risk assessments, and technology transfer packages that have successfully navigated programs through critical regulatory milestones. Matthew accelerates biologics programs from development through commercial manufacturing.
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